Estramustine phosphate capsules bp 140 mg is utilized as a part of palliative treatment of metastatic or dynamic prostate growth. Estramustine seems to go about as a generally frail alkylating specialist and confers a powerless estrogenic action. The estrogenic part of the particle goes about as a transporter to encourage specific take-up of the medication into estrogen receptor-positive cells. In view of the specific steroidal take-up, the alkylating impact of the nitrogen mustard is improved in these cells. Estramustine phosphate is promptly dephosphorylated amid assimilation, and the significant metabolites in plasma are estramustine, the estrone simple, estradiol, and estrone.
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Additional information :
- Dosage in prostate cancer
- 14 mg/kg/day (extend, 10 to 16 mg/kg/day) in 3 to 4 partitioned dosages for 30 to 90 days preceding surveying for continuation of treatment. Proceed with treatment as long as reaction is ideal.
- General advice
- Control with water 1 h or more previously or 2 h after suppers.
- Hypertension; chf; edema; expanded danger of cerebrovascular mishap; mi, thrombosis.
- Dormancy; enthusiastic lability; sleep deprivation.
- Rash; dry skin; simple wounding.
- Diminished glucose resistance; bosom delicacy or development.
- Sickness; retching; looseness of the bowels; anorexia; fart; lifted lfts.
- Diminished glucose resistance; bosom delicacy; bosom development.
- Leukopenia and thrombocytopenia have been accounted for in few patients.
- Leg spasms.
Emcyt (Generic) Estramustine phosphate 140mg Capsule:-
|Brand Name: ||X-Trant |
|Generic Name: ||Estramustine phosphate 140mg Capsule |
|Contents: ||Estramustine phosphate 140mg Capsule |
|Form: ||Capsule |
|Manufacturer ||Natco India Ltd |
|Strength: ||140mg |
|Packing: ||Price Per pack of 100 Capsule|